Journal of Steroids & Hormonal Science

ISSN - 2157-7536


Aldosterone: A Homeostatic Stabilizer

Astha Sharma

Aldosterone is important for electrolyte and fluid homeostasis, as well as blood pressure management. The “classical” concept of aldosterone activity is that it stimulates sodium reabsorption and potassium secretion by targeting epithelia of the distal colon and renal nephron. Aldosterone interacts to steroid receptors in these cells, causing them to translocate to the nucleus, where they control gene expression with the induced proteins that stimulate transport. This “genomic” activity is 0.5 h-1.0 h late and is dependent on transcription and translation. Aldosterone's activities have recently been reported as being more fast and independent of transcription and translation. Aldosterone, a steroid hormone produced in the zona glomerulosa of the adrenal cortex, is important for electrolyte and fluid balance.