Biological Systems: Open Access

ISSN - 2329-6577



Antibacterial Activity of Rhazya stricta Non-alkaloid Extract against Methicillin-Resistant Staphylococcus aureus

Raziuddin Khan*, Mohammed N Baeshen, Kulvinder S Saini, Roop S Bora. Ahmed M Al-Hejin, Salim M. El-Hamidy and Nabih A Baeshen

The effect of a crude, organic, non-alkaloid extract derived from R. stricta leaves were evaluated against methicillin-resistant Staphylococcus aureus (MRSA) pathogens. Antibacterial activities were determined by zones of inhibition using a new 1% agarose well-diffusion method. Structural and morphological alterations of MRSA cells were investigated using transmission electron microscopy. The extract showed antibacterial activities against MRSA pathogens. The extract inhibited growth, with zones of inhibition ranging between 6 and 19 mm. Transmission electron microscopy revealed that the extract distorts the cellular architecture of MRSA pathogens. Crude organic non-alkaloid extract derived from R. stricta leaves might serve as a novel antibiotic agent to prevent or treat lifethreatening MRSA infections.