Journal of Diabetes & Metabolism

ISSN - 2155-6156



Blunted Weight Loss at Incident Diabetes is a Strong Marker for Elevated Insulin Resistance in Type 2 Diabetes Mellitus

Navas Nadukkandiyil, Chakrapani Mahabala, Hanadi Al Hamad, Essa Al Sulaiti, Marwan Badri Ramadan and Noorudeen Kaladi kunnummal

Aim: To find out the relation between insulin resistance and weight status along with other clinical markers in individuals who are newly detected with type 2 diabetes mellitus.
Materials and Methods: 50 patients recently detected with type 2 diabetes mellitus were recruited in this casecontrol study. Fasting blood glucose, fasting insulin, systolic blood pressure, Glycated Hemoglobin, fasting lipid profile, anthropometric measurements and physical examinations were noted. IR was determined by Homeostasis Model Assessment (HOMA-IR). Logistic regression was done to calculate the adjusted odds ratio for weight status, other clinical and biochemical markers which predict HOMA-IR value greater than or equal to 2.5.
Results: The odds ratio for weight status was 44.338 (p=0.022, 95%CI: 1.743 – 1127.683). Odds ratio for Acanthosis Nigricans, shin spots, truncal obesity, lipid profile, HbA1c, BMI, waist-hip ratio were not significant. Difference in fasting blood sugar (p=0.001), fasting insulin (p<0.001), HOMA-IR (p<0.001), BMI (p=0.003) and waist hip ratio (p<0.001) were statistically significant among those who did not have weight loss compared to those who had weight loss. Difference in lipid profile and urine microalbumin were not significant.
Conclusion: Our study showed that not losing weight at incident diabetes could be a marker of elevated insulin resistance.