We sought to assess the impact of prednisone therapy on nasal and IgE in plasma, eosinophils in tissue, and systemic expression of periostin and exotoxin. Techniques we contrasted the tissue levels of periostin, exotoxin, IgE, and eosinophils in the nasal and systemic airways between group 1 of patients who received only nasal steroids prior to FESS and group 2 of patients who received oral steroids such as prednisone. Results patients receiving prednisone one week before and after surgery had periostin, exotoxin, and IgE levels in their plasma fall in a statistically meaningful way. Prednisone is a systemic steroid that significantly lowers the plasma levels of periostin, exotoxin, and IgE. Additionally, we noted reduced levels of exotoxin in the stromal, periostin in the epithelium, and eosinophils in the tissues. More research is required to identify the inflammatory markers linked to chronic rhino sinusitis. More tailored therapy might be possible if it were possible to find medications that reduce inflammatory parameters.
