gmo

General Medicine: Open Access

ISSN - 2327-5146

Abstract

Correlation between Thyroid Endocrine Status, Change in Body Weight and Macular Thickness in Obese Patients

Teresa Esposito, Bruno Varriale, Carlo Irregolare, Michele Lanza, Angelica Perna, Giuseppe Paolisso, Marcellino Monda

Objective: Study the co-relationship between thyroid status, obesity and macular thickness (MT) since from ophthalmic point of view, regulation of the aqueous-lipid balance resulted altered.

Methods: Obese patients (40), 20 males and 20 females, aging between 30-50 years have been enrolled in this study. All patients underwent to both biochemical and OTC evaluation.

Results: After a low-calorie diet, low fat and low salt, a remarkable weight change; weight fat mass (-17%), lean body mass (+9.0%), BMI (-13%) and body weight (-13%) were achieved. All blood parameters significantly lowered: uric acid (-45%), bilirubin (-46%), total cholesterol (-25%), HDL (+63%), LDL (-17%), triglycerides (-37%), and circulating glucose (-13%). A significative reduction of FT3, FT4 and TSH has also been observed. The reduction of the MT was also significant (-7.5%). Significant correlations between the MT detected pre- and post-treatment and lean mass (p<0.005), BMI post-treatment (p<0.011), BMI reduction (p<0.022) and body weight reduction (p<0.027). Finally, the same significant correlations are also present between the MT detected post-treatment and posttreatment lean mass (p<0.007), post-treatment BMI (p<0.007), BMI reduction (p<0.045) and body weight reduction (p<0.042).

Conclusions: There is a correlation between body and blood parameters variations, thyroid endocrine status and MT changes in obese patients undergone hypo caloric diet.

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