General Medicine: Open Access

ISSN - 2327-5146


Evaluation of Diagnostic Accuracy of Diffusion Weighted Imaging Sequences in Comparison with Other Sequences of Multi-parametric Imaging for Diagnosis of Peripheral Zone Prostate Cancer

Navid Sarmast Alizadeh, Fariborz Faeghi, Mahyar Ghafouri, Hossein Ghanaati and Kayvan Mahdavi Khazaei

Objectives: Prostate cancer is among the most prevalent cancers between elder men. Accurate and reliable diagnosis and staging are crucial factors in planning the treatment. A number of indicators have been developed in order to help with better diagnosis of prostate cancers ranging from trans-rectal ultrasonography, assessing the PSA antigen, magnetic resonance imaging, MRI guided or Ultrasonography guided biopsy. Multi-parametric magnetic resonance imaging is a new trend in diagnosis and differentiating of prostatic lesions. It uses the cutting edge technology to make reliable and optimized diagnosis about focal lesions of prostate. Current study aims to compare the efficacy of mp-MRI compared with TRUS biopsy results with focus on diffusion weighted imaging.

Methods: 42 patients were examined between 2017 and 2018 prior to doing TRUS biopsy. The mp-MRI and TRUS biopsy findings were cross-referenced. Both mp-MRI and biopsy findings were analyzed. Sensitivity, specificity, positive predictive value and negative predictive value were assessed for each MRI sequence and biopsy.

Results: Overall sensitivity, specificity, PPV and NPV for mp-MRI were 72.72%, 88.89%, 96% and 47.06%.

Conclusion: Mp-MRI can be quite helpful in diagnosis and staging of PCa especially when it comes to using DWI in combination with other sequences. High sensitivity is a major advantage but adequate studies are needed to be done in order to benefit from efficacy and reliability of mp-MRI.