From time immemorial therapeutic potential of Curcuma longa is known. In present study an effort has been made to assess the hypoglycemic, anticholesterolmic, anti-ureatic, anti-creatinic and Oral Glucose Tolerance Test (OGTT) activity of Curcuma longa juice in alloxan monohydrate induced experimental animal model. Rats were acclimatized for 7 days in lab temperature. All animals were given standard water and pellet diet. Diabetes was induced in rats with the help of alloxan monohydrate (130 mg/kg body weight). After alloxan monohydrate injection rats were separated and treatment started with Curcuma longa juice and insulin. A marked rise in fasting blood glucose, serum cholesterol, serum creatinine, serum urea level were observed in diabetic control rats when compared to normal control rats. Anti- hyperglycemic, anti-cholesterolmic, anti-creatinic, anti-ureatic activity observed in Curcuma longa fresh root juice administered rats on 10th, 20th , 30th and 40th days post treatment. Anti-hyperglycemic, anti-cholesterolmic, anti- ureatic, anti-cratinic activity was found almost similar effective like insulin treatment group. It is hope that present investigation will be helpful in establishing a scientific basis for anti-diabetic, anti-cholesterolmic, anti-creatinic, antiureatic effects in experimental animal model. The results are (<0.05) statistically significant.