Journal of Next Generation Sequencing & Applications

ISSN - 2469-9853

+44 1250400002


Identification of human genes and its genomics functions via miRNAs of C. elegans on bioinformatics platforms

Shashi Prabha Agrawal, Mrityunjay Kumar Sinha and Rajnish Kumar

Very recently microRNAs (miRNAs) have emerged as an important elements of gene regulatory networks. In present study, we use Caenorhabditis elegans as a model for identification of targeted genes. In this study, we select 113 precursors and 26 miRNAs retrieves from miRBase and these 26 miRNAs target 610 genes in human. In this prediction, we found exact name of potential genes with their exact name and functions. These potential genes regulate various genomic function with oncogenic transformation. The disease regulated by these potential genes are myelogenous leukemia, Alzheimer's disease, spinal muscular atrophy, poly cystic kidney disease, muscular dystrophyLoeys-Dietz aortic aneurysm syndrome (LDAS) adermatoglyphia, Parkinson disease, lymphoblastic leukemia, hypervalinemia, hyperleucine-isoleucinemia, giant axonal neuropathy (GAN), Turner's syndrome, Klinefelter's syndrome, Triple X syndrome, Color blindness, hemophilia, and Duchenne muscular dystrophy etc.