Dermatology Case Reports

ISSN - 2684-124X


Keratoderma as a Paraneoplastic Sign on NSCLC Patient - Case Report

Esti Shamba, Ephraim Shamba and Nir Peled

Palmoplantar keratoderma is a dermatosis that presents as hyperkeratosis of the palms and soles. Skin disorders of the feet can affect the glabrous skin on the dorsal aspects, or the thick skin on the plantar aspectsthereof, or both. Some can affect one foot, and others both. These diseases can be inflammatory, genetically inherited, infectious orneoplastic in origin. It is important to identify them and to start treatment early. If not treated, some may lead to severe pain on walking, inability to wear shoes, or even amputation with serious disability. We present a patient with severe treatment-resistant keratoderma of the feet, in addition to a long-standing dry cough. Because of the cough, a CT scan of the chest was done and a 2.5×2.5 cm nodule was detected in the left lower lobe of the lung. A biopsy confirmed the diagnosis of non-small cell lung cancer (NSCLC) stage IA. It was resected entirely with left lower lobectomy. The keratoderma resolved spontaneously within a few weeks of surgery.