Feline diabetes mellitus (DM) is a complex and increasingly prevalent metabolic disorder that shares similarities with human diabetes. This review aims to elucidate the pathophysiological continuum encompassing prediabetes, diabetes, and the intricacies of diabetic remission in felines. The etiological factors contributing to feline diabetes, including genetic predisposition and environmental influences, are explored. The pathophysiology involves disruptions in insulin secretion, insulin action, and glucose metabolism, leading to chronic hyperglycemia. Feline prediabetes, often underdiagnosed, is characterized by early metabolic abnormalities preceding overt diabetes. Understanding the transition from prediabetes to diabetes and the factors influencing diabetic remission is crucial for effective clinical management. This review provides a comprehensive examination of the molecular and physiological events involved in feline diabetes, offering insights into potential therapeutic targets and preventive strategies for this prevalent feline health concern.
