Fofie Ybn*, N Cho Al, Coulibaly T, Kouassi G, Kouassi M, Maiga-Ngouandi, Kone-bamba Diénéba and Kouakou Th
Introduction: Psathyrella tuberculata is recognized in Africa and particularly in West Africa for its many therapeutic properties. For decades, this mushroom has been the subject of several scientific studies in order to highlight its various therapeutic properties, proven in traditional medicine, and to understand its mechanism of action.
Objective: It is within this framework that this research work falls, which is a contribution to the study of Psathyrella tuberculata a food mushroom.
Material and methods: The material was the whole mushroom (Psathyrella tuberculata) including the stem and the cap. The experimental study first concerned the identification of the drug by macroscopic and micrographic description. Then, the secondary metabolites were sought and then assayed by HPLC. Then the biochemical constants were calculated after trials in triplicate. The experimental study focused on the total aqueous extract obtained by the decoction method. After extraction and phytochemical analyzes, the antihyperglycemic effect in vivo in Wistar rats was evaluated. This hyperglycemia was induced by oral overload with 30% glucose. Also, other parameters.
Results: The phytochemical analysis of Psathyrella tuberculata based on staining and/or precipitation reactions revealed the presence of heterogeneity of chemical groups (saponins, terpenes, sterols, alkaloids, quinonics, polyphenols, flavonoids). The results obtained on rat blood glucose levels showed that the product caused a significant drop in blood sugar levels after oral glucose overload. Psathyrella tuberculata is therefore active in rats given glucose overload, but its action on fasting blood sugar is not significant. The pharmacological study on the activity of Psathyrella tuberculata shows a decrease in blood glucose in rats given an oral glucose overload (post-meal glucose).
Conclusion: Consequently, Psathyrella tuberculata could be recommended as food to diabetics as well as in a person wanting to prevent diabetes.
