Journal of Steroids & Hormonal Science

ISSN - 2157-7536


Role of Androgen: Overview

Reeman Neonpough*

Androgens are C-19 steroid hormones produced predominantly by the testis and adrenal cortex [1].Androgens, the most prominent male sex steroids, are essential for the formation of the male phenotype throughout embryogenesis and the attainment of sexual maturity at puberty. Androgens are still required for the maintenance of male reproductive function and behavior throughout maturity. Androgens impact a wide range of nonreproductive tissues, including skin, bone, muscle, and the brain, in addition to its effect on reproduction [2]. The androgen receptor, a member of the vast superfamily of ligand-activated nuclear hormone receptors, is where androgens, primarily Testosterone (T) and 5-Dihydrotestosterone (DHT), exert the majority of their actions [3]. Androgens have two natural ligands: testosterone and its more potent metabolite, 5-dihydrotestosterone, both of which bind to AR and trigger transcriptional activation of target genes. As a result, male phenotypic and reproductive function, as well as other tissues such as bone and muscle, are promoted and maintained