Sangeeta N, Shaini L, Gomi Basar, Soni Devi, Vanlal Chhuangi, Kanak Kanti Mandal, Radhe Natung, Ajit Kumar Y, Singh WG and Amuba Singh M
Objective: To estimate the serum homocysteine and uric acid levels in normal and pre-eclamptic patients and to find out any correlation between these parameters and pre-eclampsia
Study design and setting: Cross-sectional study; Dept. of Biochemistry in collaboration with Department of Obstetrics and Gynaecology, Regional Institute of Medical Sciences (RIMS); Imphal (Manipur), India.
Methods: Data collected from 50 pre-eclamptic pregnant women and 25 normotensive pregnant women admitted in Antenatal ward, Department of Obstetrics and Gynaecology, RIMS Hospital. The blood samples were collected from these patients and analyzed for serum homocysteine and uric acid level.
Results: The serum homocysteine and uric acid levels were found to be significantly higher in preeclamptic cases than in normal controls. Mean ± SD of uric acid and homocysteine levels were 8.82 ± 1.68 mg% and 10.32 ± 2.52 μmol/l respectively in the cases compared to 4.06 ± 0.96 mg% and 3.55 ± 1.25 μmol/l in the controls. A positive correlation was found between the serum uric acid level, homocysteine and blood pressure. Thus the study showed a strong association between increased uric acid, blood pressure and homocysteine levels.