Prescription drugs, also known as prescription medications, are pharmaceuticals dispensed only with a valid medical prescription due to their potential for misuse and the need for professional oversight. This article provides a comprehensive overview of prescription drugs, distinguishing them from Over-the-Counter (OTC) medications. It explores the regulatory frameworks governing prescription drugs across various jurisdictions, with a focus on North America. The historical origins of the term "prescription" are examined, alongside the role of patient information leaflets in ensuring safe and informed drug use. This analysis highlights the significance of prescription drugs in modern medicine while addressing the challenges associated with their regulation and misuse.