Noninsulin medications have become an important part of the management of diabetes in children and adolescents, particularly those with Type 2 diabetes and insulin resistance. This article reviews the use of noninsulin medications in the hospitalized pediatric population, emphasizing their safety, efficacy, and role in glucose control. We discuss various classes of noninsulin diabetes medications, such as oral antihyperglycemics, glucagon-like peptide-1 receptor agonists (GLP-1RAs), and SGLT-2 inhibitors, along with their indications, clinical benefits, and challenges in the inpatient setting. The article also highlights considerations for appropriate medication selection, potential side effects, and monitoring requirements for hospitalized children and adolescents with diabetes.
