Biomedical Investigation Unit in Cancer, UNAM Institute of Biomedical Investigation / National Institute of Cancerology, Mexico
Review
Understanding tumor anabolism and patient catabolism in cancer-associated cachexia
Author(s): Alfonso Duenas-Gonzalez
Cachexia is a multifactorial paraneoplastic syndrome commonly associated
with advanced stages of cancer. Cachexia is responsible for poor responses
to antitumoral treatment and death in close to one-third of affected patients.
There is still an incomplete understanding of the metabolic dysregulation
induced by a tumor that leads to the appearance and persistence of
cachexia. Furthermore, cachexia is irreversible, and there are currently no
guidelines for its diagnosis or treatments for it. In this review, we aim to
discuss the current knowledge about cancer-associated cachexia, starting
with generalities about cancer as the generator of this syndrome, then
analyzing the characteristics of cachexia at the biochemical and metabolic
levels in both the tumor and the patient, and finally discussing current
therapeutic approaches to treating cancer-associate.. View More»
DOI:
10.35248/2155-6156.1000942
