Institute of Pharmacy, Pranveer Singh Institute of Technology Kanpur, India
Research Article
Formulation Development, Optimization and in Vitro evaluation of Gas based Gastroretentive Drug Delivery System of Anti Diabetic Drug
Author(s): Nirmal Morya, Komal Verma
Oral route is most convenient route of drug administration. Objective of
this study was to develop a gas generating drug delivery system of MH with
the help of different viscosity grades of hydroxyl propyl methyl cellulose to
obtain continuous release and provide buoyancy in the stomach. HPMC K15,
HPMC K100M, HPMC K100LVCR were use as release controlling polymer.
Citric acid, Sodium bicarbonate was use gas forming compounds. Design
of experiment (DoE) is applied by using JMP software and formulate 17
batches obtain through DoE. In vitro characterization was performed for all
the formulation. Precompression parameters were found to be 0.41±0.121
gm/cc bulk density, 0.608±0.179 gm/cc tapped density and good flow
properties. Post compression parameters were 15.0±0.009 kp hardness,
7.23±0.005 mm thickness, and 95.29±0.021.. View More»
DOI:
10.35248/2155-6156.1000940
