ijddr

International Journal of Drug Development and Research

ISSN - 0975-9344

Research Article - (2018) Volume 10, Issue 2

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Effects of Coenzyme Q10 on Biochemical Markers of Hepatic Necroinflammation in Patients with Nonalcoholic Fatty Liver

 

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Abstract

Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is a common metabolic liver disorder that can progress to cirrhosis. Up to now, there is no established treatment for this disease. Methods: We randomly assigned 55 adults with NAFLD to receive Coenzyme Q10 (CoQ10) 60 mg daily (30 subjects) or vitamin E 800 unit daily (25 subjects) for 3 months to assess the effect of CoQ10 versus vitamin E on BMI, ALT, AST, ALK-P, PT, Bilirubine, ALB, Ferritin, TG, Total Cholestrol, FBS, Serum Insuline, LDL, HDL, Total Anti Oxidant Capacity (TAC) before and after intervention. Results: In CoQ10 group there was a significant improvement in AST, ALT, TAC (P value<0.0001), Ferritin, Total bilirubin, GGT (p value<0.01), HDL (p value<0.05). In vitamin E group there was a significant improvement in AST, ALT, TAC, Ferritin, GGT, HDL (p value<0.01). There was not significant improvement in FBS, Insulin resistance and other lipid profile in both groups. Conclusion: Our study assigned that 60 mg CoQ10 is effective on improvement of noninvasive liver parameters in NAFLD. We suggest longer duration treatment and with larger dosage. We also suggest a large study with biopsy control for the assessment the effect of CoQ10 in NAFLD.

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Copyright:This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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