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Archivos de Medicina

ISSN - 1698-9465

- (2011) Volume 7, Issue 3

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Estilo de vida y riesgo de padecer demencia

 

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Abstract

A pesar de la escasez de estudios aleatorizados, la evidencia acumulada hasta la fecha procedente de estudios observacionales ya permite definir con cierta claridad la existencia de hábitos relacionados con el estilo de vida que actúan como factores de riesgo y hábitos protectores para el desarrollo de demencia. La dieta Mediterránea, la actividad física regular, hábitos de sueño regulares, la estimulación cognitiva y una vida socialmente activa son los factores relacionados con el estilo de vida que permitirían enlentecer el desarrollo de demencia y serían especialmente aconsejables a la población en general y especialmente a pacientes con deterioro cognitivo leve. Estas conclusiones deberían ser trasladadas en forma de recomendaciones generales a las políticas de protección de salud de los organismos sanitarios. Son necesarios estudios aleatorizados que permitan confirmar los resultados de los estudios observacionales, conocer los mecanismos de acción y definir recomendaciones concretas del estilo de vida para prevenir el desarrollo de demencia.

References

  1. Washington DC: APA; 2000. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-IV-TR), 4 ed, text revision.
  2. Alzheimer’s Disease International. World Alzheimer Report 2009 –Executive Summary. URL: https://www.alz.co.uk/research/files/ WorldAlzheimerReport-ExecutiveSummary.pdf
  3. Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM. Forecasting the global burden of Alzheimer’s disease. Alzheimers Dement 2007; 3: 186-91
  4. Petersen, R.C. Mild cognitive impairment: transition between aging and Alzheimer’s disease. Neurología 2000;15:93-101
  5. Reisberg, B.; Ferris, S.H.; de Leon, M.J.; Crook, T. The global deterioration scale for assessment of primary degenerative dementia”. Am J Psychiatry 1982;139:1136-9
  6. Zelinski, E.M.; Kennison, R.F. The Long Beach longitudinal study: evaluation of longitudinal effects of aging on memory and cognition. Home Health Care Serv Q 2001;19(3):45-55
  7. Amieva H, Letenneur L, Dartigues J-F, Rouch-Leroyer I, Sourgen C, D’Alchée-Birée F, Dib M, Barberger-Gateau P, Orgogozo J-M, Fabrigoule C: Annual Rate and Predictors of Conversion to Dementia in Subjects Presenting Mild Cognitive Impairment Criteria Defined according to a Population-Based Study. Dement GeriatrCognDisord 2004;18:87-93
  8. Lange, K.L.; Bondi, M.W.; Salmon, D.P.; Galasko, D.; Delis, D.C.; Thomas, R.G.; Thal, L.J. Decline in verbal memory during preclinical Alzheimer’s disease: examination of the effect of APOE genotype. J IntNeuropsychol Soc. 2002;8:943-55
  9. Reiman EM, Caselli RJ, Yun LS, Chen K, Bandy D, Minoshima S, Thibodeau SN, Osborne D. Preclinical evidence of Alzheimer’s disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med. 1996;334(12):752-8
  10. Hsiung GY, Sadovnick AD, Feldman H. Apolipoprotein E epsilon4 genotype as a risk factor for cognitive decline and dementia: data from the Canadian Study of Health and Aging. CMAJ. 2004;171(8):863-7
  11. Hughes T, Ganguli M. Factores de riesgo de demencia en la vejezmodificables en lasetapasmedias de la vida. Rev Neurol 2010; 51: 259-62.
  12. DeKosky ST, Marek K. Looking backward to move forward: early detection of neurodegenerative disease. Science 2003;302: 830- 4.
  13. Launer LJ. The epidemiologic study of dementia: a life-long quest? Neurobiol Aging 2005; 26: 335-40.
  14. Duron E, Hanon O. Vascular risk factors, cognitive decline, and dementia. Vasc Health Risk Manag 2008; 4: 363-81
  15. Morris MC. Nutritional/dietary risk reduction factors for Alzheimer’s disease and cognitive decline in older adults: foods. Published abstract from the Preventing Alzheimer’s Disease and Cognitive Decline NIH State-of-the-Science Conference. April 26-28, 2010
  16. Smith AD, Smith SM, de Jager CA, Whitbread P, Johnston C, et al. (2010) Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial. PLoS ONE 5(9): e12244
  17. Morris MC. Diet and Alzheimer’s disease. What the evidence shows. Med Gen Med 2004;6:48
  18. Laurin D, Masaki KH, Foley DJ, White LR, Launer LJ. Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu-Asia Aging Study. Am J Epidemiol 2004;159:959-67
  19. Hughes TF, Andel R, Small BJ, Borenstein AR, Mortimer JA, Wolk A, et al. Midlife fruit and vegetable consumption and risk of dementia in later life in Swedish twins. Am J GeriatrPschiatry 2010; 18: 413-20.
  20. Laitinen MH, Ngandu T, Rovio S, Helkala EL, Uusitalo U, Viitanen M, et al. Fat intake at midlife and risk of dementia and Alzheimer’s disease: a population-based study. Dement Geriatr Cog Disord 2006; 22: 99-107.
  21. Cederholm T, Palmblad J. Are omega-3 fatty acids options for prevention and treatment of cognitive decline and dementia? CurrOpinClinNutrMetab Care. 2010;13(2):150-5
  22. Van de Rest O, Geleijnse JM, Kok FJ, van Staveren WA, Dullemeijer C, Olderikkert MG, et al. Effect of fish oil on cognitive performance in older subjects. A randomized, controlled trial. Neurology 2008; 71: 430-8.
  23. Quinn JF, Raman R, Thomas RG, Yurko-Mauro K, Nelson EB, Van Dyck C, Galvin JE, Emond J, Jack CR Jr, Weiner M, Shinto L, Aisen PS. Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial. JAMA. 2010 Nov 3;304(17):1903-11
  24. urko-Mauro K, McCarthy D, Rom D, Nelson EB, Ryan AS, Blackwell A, Salem N Jr, Stedman M; on behalf of the MIDAS Investigators. Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement. 2010; 6:456-464
  25. Refolo LM, Malester B, LaFrancois J, Bryant-Thomas T, Wang R, Tint, GS, et al. Hypercholesterolemia accelerates the Alzheimer’s amyloid pathology in a transgenic mouse model. Neurobiol Dis 2000; 7: 321-31
  26. Scarmeas N, Stern Y, Mayeux R, Manly JJ, Schupf N, Luchsinger JA. Mediterranean diet and mild cognitive impairment. Arch Neurol. 2009;66(2):216-25
  27. Witte A, Jansen S, Schirmacher A, Young P and FlöelA . COMT Val158Met polymorphism modulates cognitive effects of dietary intervention. Front. Ag. Neurosci. 2010;2:146
  28. Rovio S, Kåreholt I, Helkala EL, Viitanen M, Winblad B, Tuomilehto J, Soininen H, Nissinen A, Kivipelto M. Leisure-time physical activity at midlife and the risk of dementia and Alzheimer’s disease. Lancet Neurol. 2005;4(11):705-11
  29. Andel R, Crowe M, Pedersen NL, Fratiglioni L, Johansson, B, Gatz M. Physical exercise at midlife and risk of dementia three decades later: a population-based study of Swedish twins. J Gerontol A BiolSci Med Sci 2008; 63A: 62-6.
  30. Yamada M, Kasagi F, Sasaki H, Masunari N, Mimori Y, Suzuki G. Association between dementia and midlife risk factors: the Radiation Effects Research Foundation Adult Health Study. J Am GeriatrSoc 2003; 51: 410-4.
  31. Lautenschlager NT, Cox KL, Flicker L, Foxter JK, Van Bockxmeer FM, Xiao J, et al. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA 2008; 300: 1027-37.
  32. Geda YE, Roberts RO, Knopman DS, Christianson TJ, Pankratz VS, Ivnik RJ, Boeve BF, Tangalos EG, Petersen RC, Rocca WA. Physical exercise, aging, and mild cognitive impairment: a population-based study. Arch Neurol. 2010;67(1):80-6
  33. Voss MW, Prakash RS, Erickson KI, Basak C, Chaddock L, Kim JS, Alves H, Heo S, Szabo AN, White SM, Wójcicki TR, Mailey EL, Gothe N, Olson EA, McAuley E and Kramer AF (2010) Plasticity of brain networks in a randomized intervention trial of exercise training in older adults. Front. Ag. Neurosci. 2:32
  34. Foster PP, Rosenblatt KP and Kuljiš RO (2011) Exercise-induced cognitive plasticity, implications for mild cognitive impairment and Alzheimer’s disease. Front. Neur. 2:28. doi: 10.3389/ fneur.2011.000
  35. Singh-Manoux A, Hillsdon M, Brunner E, Marmot M. Effects of physical activity on cognitive functioning in middle age: evidence from the Whitehall II prospective cohort study. Am J Public Health. 2005 Dec;95(12):2252-8
  36. Jennifer Weuve; Jae Hee Kang; JoAnn E. Manson; Monique M. B. Breteler; James H. Ware; Francine Grodsteinl Physical Activity, Including Walking, and Cognitive Function in Older Women. JAMA. 2004;292(12):1454-1461
  37. Renaud M, Maquestiaux F, Joncas S, Kergoat M and Bherer L (2010). Effects of three months of aerobic training on response preparation in older adults. Front. Ag. Neurosci. 2:148.
  38. Cronk BB, Johnson DK, Burns JM; and the Alzheimer’s Disease Neuroimaging Initiative. Body Mass Index and Cognitive Decline in Mild Cognitive Impairment. Alzheimer Dis AssocDisord. 2010;24(2):126-30
  39. Deborah Gustafson etál. (etálii). An 18-year follow-up of overweight and risk of Alzheimer disease. Arch Intern Med 2003;163:1524-1528.
  40. Sturman, M. T., de Leon, C. F. Mendes, Bienias, J. L., Morris, M. C., Wilson, R. S., Evans, D. A. Body mass index and cognitive decline in a biracial community population. Neurology 2008 70: 360-367
  41. Luchsinger JA, Cheng D, Tang MX, Schupf N, Mayeux R. Central Obesity in the Elderly is Related to Late-onset Alzheimer Disease. Alzheimer Dis Assoc Disord.2011
  42. Elwood P C, J E Gallacher, C A Hopkinson, J Pickering, P Rabbitt, B Stollery, C Brayne, Huppert F A, A Bayer. Smoking, drinking, and other life style factors and cognitive function in men in the Caerphilly cohort. J Epidemiol Community Health 1999;53:9-14
  43. Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM. Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science. 2009 Nov 13;326(5955):1005-7
  44. Benito-León, J; Bermejo-Pareja, F; Vega, S; Louis, ED. Total daily sleep duration and the risk of dementia: a prospective population-based study. European journal of neurology 2009;16(9):990–7.
  45. Fratiglioni L, Paillard-Borg S, Winblad B. An active and socially integrated lifestyle in late life might protect against dementia. The Lancet Neurology 2004, 3(6):343-353
  46. Wang HX, Karp A, Winblad B, Fratiglioni L. Late-life engagement in social and leisure activities is associated with a decreased risk of dementia: a longitudinal study from the Kungsholmen project. Am J Epidemiol. 2002;155(12):1081-7
  47. Wilson Robert S.; Carlos F. Mendes de Leon; Lisa L. Barnes; Julie A. Schneider; Julia L. Bienias; Denis A. Evans; David A. Bennett. Participation in Cognitively Stimulating Activities and Risk of Incident Alzheimer Disease. JAMA. 2002;287(6):742-748
  48. Small GW, Silverman DH, Siddarth P, Ercoli LM, Miller KJ, Lavretsky H, Wright BC, Bookheimer SY, Barrio JR, Phelps ME. Effects of a 14-day healthy longevity lifestyle program on cognition and brain function. Am J Geriatr Psychiatry. 2006;14(6):538-45
  49. Menéndez M. Recomendacionessobre el consumo de alcohol en pacientes con deteriorocognitivoleve. Neurología 2006,21(4):218
  50. Luchsinger JA, Tang MX, Siddiqui M, Shea S, Mayeux R. Alcohol intake and risk of dementia. J Am Geriatr Soc. 2004;52(4):540-6
  51. Gelber RP, Petrovitch H, Masaki KH, Ross GW, White LR. Coffee intake in midlife and risk of dementia and its neuropathologic correlates. J Alzheimers Dis. 2011;23(4):607-15
  52. Ritchie K, Carrière I, de Mendonca A, Portet F, Dartigues JF, RouaudO,Barberger-Gateau P, Ancelin ML. The neuroprotective effects of caffeine: a prospective population study (the Three City Study). Neurology. 2007;69(6):536-45Arendash GW, Cao C. Caffeine and coffee as therapeutics against Alzheimer’s disease. J Alzheimers Dis. 2010;20 Suppl 1:S117-26
  53. Santos C, Costa J, Santos J, Vaz-Carneiro A, Lunet N. Caffeine intake and dementia: systematic review and meta-analysis. J Alzheimers Dis. 2010;20 Suppl 1:S187-204
  54. Small GW, Silverman DH, Siddarth P, Ercoli LM, Miller KJ, Lavretsky H, Wright BC, Bookheimer SY, Barrio JR, Phelps ME. Effects of a 14-day healthy longevity lifestyle program on cognition and brain function. Am J Geriatr Psychiatry. 2006;14(6):538-45
  55. Lee Y, Na DL, Cheong HK, Hong CH, Back JH, Kim J, Kim SH, Kim YG. Lifestyle Recommendations for Dementia Prevention: PASCAL. J Korean Geriatr Soc. 2009;13(2):61-68

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