Journal of Diabetes & Metabolism

ISSN - 2155-6156



Analysis of Aldosterone Synthase Gene Promoter (- 344 C >T) Polymorphism in Indian Diabetic Nephropathy Patients

Pulakes Purkait, Raychodhury P, Bandhyopadhya S, Naidu JM and Sarkar BN

Aim: the aim of the present study is to evaluate the association between CYP11B2gene and type 2 diabetic nephropathy patients in Indian population.

Result: There was a significant difference in age, cholesterol, triglycerides, HDL, creatinine, BUN, Uric acid, total protein, Albumin, SBP, DBP variables except LDL Cholesterol among the study groups. The frequencies of CYP11B2 gene CC, CT, TT genotypes among the T2DNH are 16.67 %, 51.19 %, 32.14 %; in T2DM patient 10.66 %, 52.46 %, 36.88 % and 16.95%, 38.14%, 44.91% in controls respectively and we could not observe significant differences in both genotype (x2=7.289, p=0.121) and allele frequency (X2=1.82, p=0.403) of the CYP11B2 gene (-344 T>C) polymorphism between T2DNH, T2DM patients and Controls subjects.

Conclusion: Our findings do not support the hypothesis that CYP11B2 polymorphism is associated with prevalence of Type 2 diabetic nephropathy patients in Indian populations.