Saadi MM, Haque R, Tania FA and Tasnim S*
Objectives: Metabolic syndrome is a cluster of metabolic disorders including obesity, hypertension, diabetes mellitus and dyslipidemia. Insulin resistance is the underlying pathological condition for the development of metabolic syndrome. Microalbuminuria is also associated with some conditions like obesity, hypertension and diabetic nephropathy. Dyslipidemia is commonly found in obesity, diabetes mellitus and is frequently measured in our day to day clinical settings. Besides this Tg-HDL ratio is used for risk assessment coronary artery disease now a days. Therefore any association of Tg-HDL ratio with metabolic syndrome and Microalbuminuria can help our clinicians to predict metabolic derangements earlier and easily.
Study design: In this cross sectional analytical study 150 subjects were included by convenient sampling from outpatient department of endocrinology of a tertiary level hospital, Dhaka, Bangladesh.
Methods: A quantitative research has been performed to observe the relationship between the components of metabolic syndrome patients. Different statistical analysis including binary logistic regression has been performed to see the association between them.
Results: In this study, male–female ratio was almost equal, with average age 42.72(7.94).± Among the study subjects 55 were non-MetS and rest of the candidates were with MetS. Among the study subjects for presence of 3, 4 & 5 components of MetS, the average Tg-Hdl ratios were found to be 5.01, 5.76, 6.17 and risk of having higher Tg-Hdl values were 1.92, 2.26 & 2.39 times higher respectively than those without MetS. Again Risk of MetS increased by 0.53, 1.17 & 1.56 times in Q2, Q3 & Q4 respectively in comparison to Q1 of the Tg-HDL ratio of the participants. Binary logistic regression analysis was done to find out relationship between MetS and microalbuminuria with Tg-HDL ratio and was found significant. Odds ratios for MetS and microalbuminuria with respect to Tg-HDL ratio were observed as 1.30 and 1.19 with β coefficients 0.267 and 0.177 respectively. The result implies 30% and 19% more risk of developing Mets and microalbuminuria for patients with high Tg-HDL ratio (p<0.05 for all cases).
Conclusion: Tg-HDL ratio level strongly correlated with both MetS and microalbuminuria. Risk of an individual to develop MetS and microalbuminuria for high Tg-HDL ratio was found significantly higher than normal individuals. So early treatment for high Tg-HDL ratio can effectively decline the rate of progression of MetS as well as can diminish the risk of development of microalbuminuria.
