Amir Savardashtaki
West Indies
Research Article
Molecular Mechanisms Underlying the Nephrotoxicity of Cisplatin, Lead Acetate and Cyclosporine: Key Roles of Myc and Smad4
Author(s): Hassan Askari, Ehsan Raeis Abdullahi, Vahdat Poortahmasebi, Danya Abazari, Matin Asghari, Solmaz Sadeghi, Mohammad Foad Abazari, Reza Mahmoudi, Amir Savardashtaki and Mansour PoorebrahimHassan Askari, Ehsan Raeis Abdullahi, Vahdat Poortahmasebi, Danya Abazari, Matin Asghari, Solmaz Sadeghi, Mohammad Foad Abazari, Reza Mahmoudi, Amir Savardashtaki and Mansour Poorebrahim
It is well documented that use of Cisplatin, Lead acetate and Cyclosporine in the chemotherapy and medical interventions is highly associated with nephrotoxicity and interrelated comorbidities. Here, we proposed the possible molecular mechanisms responsible for nephrotoxicity of these compounds. We utilized the microarray dataset GSE59913 consisting of approximately 600 different compounds profiled in up to 8 different tissues. After analysis with GEO2R, gene expression profiles of three aforementioned compounds were integrated with protein-protein interactions (PPI) networks and topological properties of the networks were measured using Cytoscape software. We found several key genes and signaling pathways that seem to be involved in nephrotoxicity of the examined compounds. Myc and Smad4 were identified as principal players of three compounds’ nephrotoxicity through various pat.. View More»
