Bruno Rodrigues
Heart Institute (InCor),
Av. Dr. Eneas de Carvalho Aguiar 44 – Subsolo, São Paulo São Paulo -05403-000
Brazil
Research Article
VEGF165 Gene Therapy Improves Left Ventricular Function and Exercise Capacity in Diabetic Rats after Myocardial Infarction: Impact on Mortality Rate
Author(s): Bruno Rodrigues, Cristiano T. Mostarda, Kaleizu T. Rosa, Melissa Markoski, Nance B. Nardi, Kátia De Angelis, Maria Cláudia Irigoyen and Renato A. K. KalilBruno Rodrigues, Cristiano T. Mostarda, Kaleizu T. Rosa, Melissa Markoski, Nance B. Nardi, Kátia De Angelis, Maria Cláudia Irigoyen and Renato A. K. Kalil
Despite the increased amount of evidence about the benefits of human vascular endothelial growth factors by plasmid (pHuVEGF 165 ) based gene transfer after an ischemic event, the effects of pHuVEGF 165 therapy in diabetic hearts after myocardial infarction (MI) remains poorly investigated. We evaluated the effects of intramyocardial pHuVEGF 165 injection on left ventricular (LV) morphometry, function and blood flow, maximal oxygen consumption (VO 2 max), and the total mortality rate of diabetic rats after MI. Male Wistar rats were divided into control (C), myocardial infarction+saline injection (I+SAL), myocardial infarction+pHuVEGF 165 injection (I+VEGF), diabetes+myocardial infarction+saline injection (DI+SAL), and diabetes+myocardial infarction+pHuVEGF 165 injection (DI+VEGF). MI was induced after 15 days of streptozoto.. View More»
