Christian Cadeddu
University Hospital of Cagliari,
StradaStatale 554, Km 4.500, 09042 Monserrato (Cagliari)
Italy
Research Article
Effects of Metformin Treatment on Myocardial and Endothelial Function in Insulin Resistance Patients: A Metabolomic Study
Author(s): Christian Cadeddu, Martino Deidda, Silvio Nocco, Emanuela Locci, Efisio Cossu, Marco G Baroni, Luigi Atzori and Giuseppe MercuroChristian Cadeddu, Martino Deidda, Silvio Nocco, Emanuela Locci, Efisio Cossu, Marco G Baroni, Luigi Atzori and Giuseppe Mercuro
Introduction: Insulin resistance (IR) adversely affects cardiac performance and peripheral vasodilation reserve. Metformin, prescribed to prevent the progression of IR resistance into diabetes, has been shown to improve myocardial performance and endothelial function in insulin resistant individuals. Metabolomics in the study of the metabolite profile of a biological organism proved its efficacy in detecting metabolites changes as a result of a therapeutic intervention and, so, predicting the response.
Aim: To evaluate myocardial and endothelium-dependent vasodilatory functions in an IR population subsequent to treatment with metformin and to determine the metabolic changes associated.
Methods: Twenty consecutive patients recently diagnosed with IR were studied. All subjects underwent echocardiography with Speckle Tracking techniqu.. View More»
