Ginpreet Kaur
India
Research Article
The Effect of Murraya koenigii Extract on Therapeutic Efficacy of Amlodipine in Rats: Possible Drug-Herb Interaction
Author(s): Kalyani H Barve, Ginpreet Kaur, Aadesh Kumar and Saloni DaftardarKalyani H Barve, Ginpreet Kaur, Aadesh Kumar and Saloni Daftardar
Introduction: Murraya koenigii is commonly available condiment having a wide spectrum of pharmacological activities. It has folklore use for treatment of hypertension and is reported to have ACE inhibitory activity. Therefore, the present study is proposed to identify the antihypertensive effect of the Murraya koenigii. The increasing use of herbal medicine has raised the concern of the potential interactions between the herbs and the conventional drugs. Hence we have further tried to investigate the interactions of this extract with amlodipine, which in turn has a narrow therapeutic index.
Method: The alcoholic extract of the leaves was prepared and subjected to acute toxicity studies as per the OECD guideline 423. The extract was evaluated for its antihypertensive effect on cadmium chloride induced hypertension in rats. The extract was also co administered with amlodipine in normal ra.. View More»