Graeme A Macdonald
Australia
Research Article
A Pilot Randomised Study of the Metabolic and Histological Effects of Exercise in Non-alcoholic Steatohepatitis
Author(s): Ingrid J Hickman, Nuala M Byrne, Ilaria Croci, Veronique S Chachay, Andrew D Clouston, Andrew P Hills, Elisabetta Bugianesi, Jonathan P Whitehead, Amalia Gastaldelli, Trisha M O’Moore-Sullivan, Johannes B Prins and Graeme A MacdonaldIngrid J Hickman, Nuala M Byrne, Ilaria Croci, Veronique S Chachay, Andrew D Clouston, Andrew P Hills, Elisabetta Bugianesi, Jonathan P Whitehead, Amalia Gastaldelli, Trisha M O’Moore-Sullivan, Johannes B Prins and Graeme A Macdonald
Aims: Type 2 diabetes is a risk factor for the development and progression of non-alcoholic fatty liver disease (NAFLD). Lifestyle intervention is the principal treatment for NAFLD however the effects of exercise alone on the histological and metabolic severity of NAFLD are unclear. This study assessed the effects of 6 months exercise training and diet-induced weight loss on insulin resistance and liver histologyin overweight patients with NAFLD.
Methods: 21 patients were randomised to circuit exercise (EX) training (60 min×3/week) or dietary induced weight loss (DIWL) (-500 kcal/d). Insulin sensitivity (euglycaemic-hyperinsulinemic clamp with tracer), adiposity (CT scan) and histology (liver biopsy) were assessed at 0 and 6 months.
Results: Weight decreased by 9.7 ± 4.6% (-6.7 ± 6.3 kg p=0.02) with DIWL but was.. View More»
