Research Article
Cadherin Expression in the Nigerian and United Kingdom Breast Cancer Cases: A Comparison of Clinicopathological and Prognostic Characteristics
Author(s): Ebili HO, Iyawe VO, Iyawe VO, Banjo AAF, Salami BS, Rakha EA, Nolan C, Ellis IO and Green AREbili HO, Iyawe VO, Iyawe VO, Banjo AAF, Salami BS, Rakha EA, Nolan C, Ellis IO and Green AR
Background: The expression of the cadherins have been shown to have both clinicopathological and prognostic significance in breast cancer from different ethnic populations. However, the clinicopathological and prognostic significance of the cadherins expression in Nigerian breast cancer (BC) have hitherto not been determined. The aim of this study was therefore to describe the expression patterns of E- and P-cadherin in Nigerian and United Kingdom (UK) BC cases and to compare the clinicopathological and prognostic significance of the cadherins between the two cohorts.
Methods: Tissue microarray of about 266 formalin-fixed paraffin-embedded Nigerian and 301 UK BC samples with well-characterized clinicopathological indices were subjected to immunohistochemical staining for E- and P-cadherins and other biomarkers. These biomarkers were correlated with the patients’ clinicop.. View More»
