Hatem Mohamed Saleh
Egypt
Research Article
Association of CTLA-4 Polymorphisms with Type 1 Diabetes in the Egyptian Population
Author(s): Hatem Mohamed Saleh, Bobby Koeleman, Gábor Szénási, László Rosivall and Peter HamarHatem Mohamed Saleh, Bobby Koeleman, Gábor Szénási, László Rosivall and Peter Hamar
Background: Polymorphisms in the cytotoxic T-lymphocyte antigen 4 (CTLA-4) are associated with the risk of type 1 diabetes (T1D). Here, we investigated the most associated variants CT60 and +49 A/G and five other putative promoter SNPs for their association with T1D in the Egyptian population, a multi-ethnic group. The comparison of disease association between populations can provide further evidence for putative disease variants.
Methods: Association of seven SNPs (-1722,-1661,-651,-319, +49, -819 and +6230G>A) in the CTLA-4 gene with T1D was investigated in 396 patient and 396 control subjects of Egyptian origin. The diagnosis of T1D was made based on ketoacidosis or ketosis with acute onset and severe symptoms of diabetes mellitus at presentation and continuous dependence on insulin. Controls were negative for anti-GAD antibodies and w.. View More»
