Hideki Yamauchi
Japan
Research Article
The Exercise-Induced Improvement in hyperglycemia is Mediated by DHT Produced in the Skeletal Muscle of Zucker Diabetic Fatty Rats
Author(s): Koji Sato, Satoshi Fujita, Hideki Yamauchi, Yoko Shiroya, Hiromi Kitamura, Kumiko Minato and Motoyuki IemitsuKoji Sato, Satoshi Fujita, Hideki Yamauchi, Yoko Shiroya, Hiromi Kitamura, Kumiko Minato and Motoyuki Iemitsu
The ability of exercise to improve hyperglycemia by enhancing glucose metabolism in the skeletal muscle of type 2 diabetic patients is well established. We reported sex steroid hormones can be locally synthesized in skeletal muscle and decrease fasting blood glucose levels in obese rats. Here, we determined whether exercise-induced production of sex steroid hormones in skeletal muscle could directly reverse hyperglycemia in the Zucker diabetic fatty rat model using osmotic mini pump.
Thirty Zucker diabetic fatty rats were randomly assigned to the following groups: control, exercise, or exercise with continuous infusion of 5α-reductase inhibitor.
The results indicated 6 weeks of exercise significantly reduced serum insulin and fasting glucose levels compared to control group. Dehydroepiandrosterone, 5α-dehydrotestosterone, and 5α-reductase levels were .. View More»
