Hyun Soon Lee
Renal Pathology Laboratory, Hankook Kidney and Diabetes Institute,
Songpa-gu, Samhaksaro 93, Seoul, 138- 840
Taiwan
Review Article
Pathogenic Role of TGF- β in Diabetic Nephropathy
Author(s): Hyun Soon LeeHyun Soon Lee
About one-third of diabetic patients develop diabetic kidney disease. In renal cells, transforming growth factor- β (TGF-β) is a key regulator of extracellular matrix protein synthesis and is secreted as latent complexes. Chronic hyperglycemia in diabetic patients seems to stimulate the glomerular mesangial cells to secrete TGF- β, which is stored in the mesangial matrix and then localized to the podocyte surface. Glomerular hypertension in the diabetic kidney may upregulate angiotensin II (Ang II) in podocytes, which may activate the latent TGF- β. Activated TGF- β /Smad signaling may stimulate the podocytes to overproduce α3(IV) collagen, leading to glomerular basement membrane (GBM) thickening. Furthermore, TGF-β-induced connective tissue growth factor (CTGF) and vascular endothe.. View More»
