Jayanthy Srivalli
India
Research Article
Impact of Iron Indices, Mitochondrial Oxidative Capacity, Oxidative Stress and Inflammatory Markers on Insulin Resistance and Secretion: A Pathophysiologic Perspective
Author(s): Jayanthy Ramesh, Mohammad Ibrahim Shaik and Jayanthy SrivalliJayanthy Ramesh, Mohammad Ibrahim Shaik and Jayanthy Srivalli
Objective: To elucidate how iron deficiency anemia influence the natural history of diabetes mellitus and to study the effect of iron indices, mitochondrial oxidative capacity and oxidative stress on insulin resistance and secretion in established cases of type 2 diabetes.
Research design and methods: A comparative cross-sectional study was conducted in 40 healthy controls, 40 iron deficiency anemia (IDA), 40 type 2 diabetes without iron deficiency anemia and 40 type 2 diabetes with iron deficiency patients. All the Patients were BMI, age and sex matched. Glycemic indices, fasting serum insulin levels, iron indices, inflammatory markers, Total Antioxidation Capacity (TAOC), Mitochondrial Oxidative Capacity (MOC) were analyzed.
Results: In iron deficiency anemia there was decrease in MOC, TAOC and HOMA B (p<0.001). Iron was positively correlated with MOC which in.. View More»
