Keefe Chng
Tanzania
Research Article
Hepatic Steatosis and Fibrosis in Obese, Dysmetabolic and Diabetic Nonhuman Primates Quantified by Noninvasive Echography
Author(s): Yongqiang Liu, Haihua Gu, Hui Wang, Bingdi Wang, Xiaoli Wang, George Aoyagi, Yong-Fu Xiao, Keefe Chng, Xing Gao, Jinhu Wang, Eiketsu Sho, Yao-Ping Lin and Yi Xin (Jim) WangYongqiang Liu, Haihua Gu, Hui Wang, Bingdi Wang, Xiaoli Wang, George Aoyagi, Yong-Fu Xiao, Keefe Chng, Xing Gao, Jinhu Wang, Eiketsu Sho, Yao-Ping Lin and Yi Xin (Jim) Wang
Purpose: Patients with obesity and type 2 diabetes (T2D) are more susceptible to the occurrence of nonalcoholic fatty liver disease (NAFLD)/steatohepatitis (NASH). Although liver biopsy is still reviewed as a gold standard for the diagnosis, due to its invasiveness, high cost and variable readouts, it has limited application in large scale clinical investigation and long term following up the therapeutic benefits. This study was to apply a clinically used noninvasive echography to quantitatively evaluate the NAFLD/NASH model in dysmetabolic nonhuman primates.
Method: Noninvasive echography with computer-assisted imaging analysis was used to quantify hepatic pathological changes in 36 cynolmolgus monkeys at different dysmetabolic stage.
Result: Both hepatic/renal echo-intensity ratio (H/R=1.69 ± 0.12 vs 1.36 .. View More»
