Kenji Saka
Japan
Research Article
Liraglutide With or Without Metformin Ameliorates Liver Function and Fatty Liver in Obese Patients with Type 2 Diabetes Mellitus
Author(s): Tadashi Iwao, Kenji Saka and Eiji AndoTadashi Iwao, Kenji Saka and Eiji Ando
Objective: To evaluate efficacy of 24 weeks administration of liraglutide with or without metformin on liver parameters, visceral adipose tissue (VAT) area and liver-to-spleen attenuation (L/S) ratio between non-obese and obese patients with type 2 diabetes mellitus. Methods: A total of 57 patients with type 2 diabetes: non-obese group (N=30) and obese group (N=27) were enrolled. HbA1c, body weight, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and VAT area and L/S ratio were measured before and after the treatment. Results: In the two groups, sustained and significant reductions were observed in HbA1c, and body weight. A similar reduction was observed in AST and ALT level, but the change was greater in obese group than in non-obese group (p<0.05, p<0.05, respectively). Although reduction in VAT area did not differ in both groups, the change of L/S ratio was .. View More»
