Lars Arendt-Nielsen
Denmark
Research Article
Associations between Sensorimotor, Autonomic and Central Neuropathies in Diabetes Mellitus
Author(s): Christina Brock, Eirik Søfteland, Jens Brøndum Frøkjær, Asbjørn Mohr Drewes and Lars Arendt-NielsenChristina Brock, Eirik Søfteland, Jens Brøndum Frøkjær, Asbjørn Mohr Drewes and Lars Arendt-Nielsen
Background: Patients with long-standing diabetes mellitus (DM) are exposed to hyperglycemia and metabolic disorders associated with extensive neuronal damage. Using a bedside applicable setup, the aim was to explore whether diabetes patients suffering from sensorimotor neuropathy had co-existing autonomic and central neuropathy.
Methods: Twenty DM patients (10 women, average age 58.3 ± 12.0 years) with sensorimotor polyneuropathy and 16 healthy volunteers (HV) (9 women, age 62.6 ± 10.5 years) were recruited. Heart rate variability was recorded. Peripheral tactile detection threshold and sensation to pinprick was assessed by Von Frey-filaments. Sensitivity to pressure of the forearm extensor digitorum muscle was measured before and after conditioning pain modulation (CPM) induction by immersing the contra lateral hand into ice w.. View More»
