Le Shu
Bolivarian Rep. of Venezuela
Research Article
Association of CDKAL1 Genetic Polymorphism with Glycosylated Hemoglobin A1c Level among Non-Diabetic Chinese Adults
Author(s): Jun-yi Jiang, Hua Qiu, Gen-ming Zhao, Yi Zhou, Miao Mo, Le Shu, Lu-xi Yang, Si-yu Yu, Qing-wu Jiang, Xiao-nan Ruan and Wanghong XuJun-yi Jiang, Hua Qiu, Gen-ming Zhao, Yi Zhou, Miao Mo, Le Shu, Lu-xi Yang, Si-yu Yu, Qing-wu Jiang, Xiao-nan Ruan and Wanghong Xu
Objectives: Multiple single nucleotide polymorphisms (SNPs) have been identified as risk loci for type 2 diabetes (T2DM). This study was conducted to increase our understanding of the mechanisms through which three novel risk variants affect the risk of T2DM. Methods: 918 Chinese volunteers from Pudong New Area of Shanghai, China, were recruited in Oct-Dec, 2006. Collection of demographic and lifestyle characteristics, body measurements, bio-specimen collection and biochemistry assays were performed during the period. Genotyping of rs290487 at transcription factor 7-like 2 (TCF7L2), rs9465871 at cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1(CDKAL1) and rs1359790 at chromosome 13q31.1 were conducted using Taqman approach. Results: Genotypes of TCF7L2-rs290487, CDKAL1-rs9465871 and rs1359790 at 13q31.1 were not associated with metabolic syndrome or its compone.. View More»
