Research Article
Transplacental Passage and Subcellular Accumulation of Lanthanum within Maternal and Fetus side of Placenta: A Transmission Electron Microscopy Study
Author(s): Badri Nedra, Mhamdi Maroua, Florea Adrian, Horea Matei, Tekaya Walid-Habib, Hila Lamia, Maghraoui Samira and Tekaya LeilaBadri Nedra, Mhamdi Maroua, Florea Adrian, Horea Matei, Tekaya Walid-Habib, Hila Lamia, Maghraoui Samira and Tekaya Leila
Placenta is a privileged organ which has a storage function during pregnancy. Thus, it establishes an interface between maternal circulation and fetus. Therefore, any deviation from normal placental development may constitute a potential threat to fetus growth. In this work, we try to study the subcellular behavior as well as the effects of lanthanum (La), on placenta of gestating rats after its intraperitoneal injection under soluble solution. Using TEM, the ultrastructural observations of placenta tissues from lanthanum-treated rats showed many electron-dense surcharges in the lysosomes of maternal connective tissues from maternal part of placenta as well as syncytiotrophoblast and cytotrophoblast from fetus side of placenta respectively. At a concentration of 48 mg/kg, lanthanum was found to cause change in nucleus contouring, vacuolations, expansion of the rough endoplasmic reticu.. View More»
