Research Article
Alpha-Tocopherol Supplementation Diminishes the Renal Damage Caused by Experimental Diabetes
Author(s): Tammy Fernández Romero, Sonia Clapés Hernández, Gipsis Suárez Román, Lucía González, Sandra Rodríguez and María de losÁngeles GarcíaTammy Fernández Romero, Sonia Clapés Hernández, Gipsis Suárez Román, Lucía González, Sandra Rodríguez and María de losÁngeles García
Background: Previous studies have shown alpha- tocopherol favorable effects on biochemical markers of kidney function and tissue damage in experimental models of diabetes. However, few reports highlight its effect in organ morphology and even less its impact during pregnancy. The main goal of this study was to evaluate the effect of alpha- tocopherol supplementation on the renal tissue morphology of diabetic pregnant rats.
Methods: Diabetes was induced in female Wistar rats after intraperitoneal administration of streptozotocin. Healthy rats without any preparation were used as control subjects. Diabetic and control rats were grouped by receiving oral alpha-tocopherol 150 mg/kg/day or the vehicle during pregnancy. Euthanasia was practiced by bleeding under anesthesia at 20 days of gestation. Metabolic markers in plasma were ana.. View More»
