Misa Valo
Germany
Research Article
Markers of Myocardial Ischemia in Patients with Diabetes Mellitus and Severe Obstructive Sleep Apnea – Impact of Continuous Positive Airway Pressure Therapy
Author(s): Misa Valo, Albert Moller and Claudius TeupeMisa Valo, Albert Moller and Claudius Teupe
Introduction: Diabetes Mellitus (T2DM) and obstructive sleep apnea (OSA) are common disorders that often coexist. Both disorders are associated with an increased risk of cardiovascular complications. Repeated nocturnal hypoxia in diabetic patients suffering also from OSA may result in myocardial ischemia. We evaluated whether myocardial ischemia is detectable by ST-segment depression and elevation of high sensitive Troponin T (hs-cTnT) and N-terminal pro B-type natriuretic peptide (NT-proBNP). We also examined the effect of continuous positive airway pressure treatment (CPAP) on these markers. Methods: Fifteen patients with OSA and concomitant T2DM and 26 patients with OSA alone underwent polysomnography at baseline and under CPAP. Blood samples for hs-cTnT and NT-proBNP measurements were drawn prior and immediately after sleep. ST-segment depression was measured at the time of maximu.. View More»
