Mukundi MJ
Kenya
Research Article
1In-Vivo Antidiabetic Activity and Safety of The Aqueous Stem Bark Extract of Kleinia squarrosa
Author(s): Abdirahman YA, Juma KK, Mukundi MJ, Gitahi SM, Agyirifo DS, Ngugi MP, Gathumbi PK, Ngeranwa JJN and Njagi ENMAbdirahman YA, Juma KK, Mukundi MJ, Gitahi SM, Agyirifo DS, Ngugi MP, Gathumbi PK, Ngeranwa JJN and Njagi ENM
Kleinia squarrosa has been used traditionally to manage several diseases including diabetes, however, its efficacy and safety is not well evaluated. The aim of this study was to determine in-vivo hypoglycemic activity and safety of the aqueous stem bark extracts of this plant in male swiss white albino mice. The antidiabetic activity was screened in alloxan induced diabetic mice using oral and intraperitoneal routes. The safety of the extract was studied in mice that were orally and intraperitoneally administered with 1 g/kg body weight daily for 28 days by recording changes in body and organ weights, hematological and biochemical parameters and histology. Mineral composition was estimated using total reflection X-ray fluorescence system (TRXF) and atomic absorption spectrometry (AAS). Phytochemical composition was assessed using standard procedures. The extract showed hypoglycemic ac.. View More»
