Neetu Israni
India
Research Article
Association of Protein Tyrosine Phosphatase Non-receptor, Type 22 (PTPN22) C1858T Polymorphism with Type 1 Diabetes in North India: A Replication Study
Author(s): Rajni Rani, Neetu Israni, Avinash Kumar, Smreti Vasudevan and Jaya SinghRajni Rani, Neetu Israni, Avinash Kumar, Smreti Vasudevan and Jaya Singh
Objective: Type 1 diabetes (T1D) is a multifactorial autoimmune disorder where several genes have been associated with the disease. While the major histocompatibility complex has been shown to be the major locus, contributions of other loci in different combinations seem to have synergistic effects. PTPN22 (Protein tyrosine phosphatase non-receptor, type 22) gene encoding lymphoid tyrosine phosphatase (LYP) is a negative regulator of T cell signaling. A gain of function mutant at nucleotide position 1858 C>T has been associated with diabetes, however, it is reported to be absent in Asians. We have studied PTPN22 C1858T polymorphism in T1D patients from North India since there are no reports from this region.
Methods: PTPN22 C1858T polymorphism was studied in 250 T1D patients and 480 healthy controls using polymerase chain.. View More»
