Richard J. Roman
Tanzania
Review Article
Comparison of the Development Diabetic Induced Renal Disease in Strains of Goto-Kakizaki Rats
Author(s): Naoki Kojima, Tiffani N. Slaughter, Adrienne Paige, Sota Kato, Richard J. Roman and Jan M. WilliamsNaoki Kojima, Tiffani N. Slaughter, Adrienne Paige, Sota Kato, Richard J. Roman and Jan M. Williams
This study compared temporal changes in renal hemodynamics, proteinuria and the development of renal disease in Goto-Kakizaki (GK) type II diabetic ratsthat are resistant to the development of diabetic nephropathy and a genetically modified GK substrain (T2DN) carrying the mitochondrial genome and other alleles from Fawn hooded-hypertensive (FHH) rats is more susceptible to the development of renal injury. Both GK and T2DN rats were diabetic (>250 mg/ dL) and blood glucose levels were not significantly different at 3, 6 and 18 months of age. Blood pressure was also similar in both strains at all 3 ages. Renal blood flow (RBF) was 45% higher in 3 month old T2DN rats than GK rats but glomerular filtration rate (GFR) was similar. T2DN rats exhibited a progressive increase in proteinuria from 41 ± 2 to 524 ± 50 mg/day and.. View More»
