Rodolfo Rosseto Rampaso
Brazil
Research Article
Progressive Resistance Exercise Training Attenuated Renal Damages, but did not improve Muscle Force in STZ-Induced Diabetic Rats
Author(s): Kleiton Augusto Santos Silva, Ralmony de Alcântara Santos, Marcelo Rocino Arlotti, Luciana Jorge, Rafael da Silva Luiz, Rodolfo Rosseto Rampaso, Tatiana Sousa Cunha and Nestor SchorKleiton Augusto Santos Silva, Ralmony de Alcântara Santos, Marcelo Rocino Arlotti, Luciana Jorge, Rafael da Silva Luiz, Rodolfo Rosseto Rampaso, Tatiana Sousa Cunha and Nestor Schor
A type of exercise (Resistance Exercise Training – RET) that is markedly applied to increase muscle mass has been prescribed to prevent muscle atrophy from catabolic conditions such as, diabetes and chronic kidney disease. However, how this type of exercise modulates renal system remains unclear. It prompted us to apply progressive RET to STZ-induced diabetes rats in order to investigate renal environment. Progressive RET was applied to Wistar rats under following exercise program: 6 to 12 climbs/day, 5 days/week, 8 weeks, at 50 to 80% of maximal loading test. After streptozotocin injection, animals were divided into four groups: two control groups (non-exercised and exercised) and two diabetic groups (non-exercised and exercised) with 4 to 6 rats/group. Kidney weight (KW), muscle weight, proteinuria and protein level (assessed by Western blot and multiplex technology) were dete.. View More»
