Saadia Shahzad Alam
Pakistan
Research Article
Effect of High Dose Thiamine Therapy on Risk Factors in Type 2 Diabetics
Author(s): Saadia Shahzad Alam, Samreen Riaz and Waheed Akhtar MSaadia Shahzad Alam, Samreen Riaz and Waheed Akhtar M
Background: Traditional and more recently, a host of nontraditional risk factors of type 2 diabetes mellitus have adopted significance as promoters of the pathologies associated with this disease. High dose Vitamin B1 (thiamine) has been found at preclinical level to play an ameliorative role through a number of intracellular metabolic pathways. In order to demonstrate this clinically, pioneering research on the effect of high dose thiamine on associated markers of biochemical dysfunction, incipient diabetic nephropathy, hemostasis (plasminogen activation inhibitor/PAI-1), oxidative stress (plasma thiols) and second messenger signaling (protein kinase C/ PKC ) was conducted.
Subjects and methods: Type 2 diabetics were enrolled in randomized, double blind placebo controlled clinical trial for 6 months. Patients were divided i.. View More»
