Sabodash EE
Ukraine
Research Article
HNOD2/CARD15 and JAK2 in Ukranian Inflammatory Bowel Diseases Cohort
Author(s): Dorofeyev AE, Rassokhina OA, Kishenya MS, Derkach IA, Kiriyan EA and Sabodash EEDorofeyev AE, Rassokhina OA, Kishenya MS, Derkach IA, Kiriyan EA and Sabodash EE
Background: Genetic predisposition is the key factor for inflammatory bowel diseases (IBD). NOD2/CARD15 (nucleotide-binding oligomerization domain family, member 2) is one of the most known genes in IBD and comes for clinical practice, especially Crohn?s disease (CD). For IBD predisposition analysis this gene mutations is useful and predict more aggressive disease course. NOD2/CARD15 is responsible for recognizing of pathogen-associated molecular patterns. Activation of Janus kinase-2 (JAK2) transcription pathway leads to expression of pro-inflammatory cytokines and induce immune response. JAK2 may be considered as a potential gene-candidate to IBD susceptibility. Genetic predisposition with polymorphism of NOD2/CARD15, JAK2 can play important role in pathogenesis of inflammatory bowel diseases.
Aim: to characterize genetic susceptibility to ulcerative colitis (UC), Crohn?s disease (C.. View More»
