Shuba Varshini Alampalli
India
Research Article
Genome Resequencing Reveals Single Nucleotide Polymorphism and Repeat Regions in Giardia lamblia Indian Isolate
Author(s): Shuba Varshini Alampalli, Akshay C Uttarkar, Suchithra Ventakesh, Sivarajan T Chettinar, Rishi Kumar Nageshan, Vidya Niranjan and Utpal S TatuShuba Varshini Alampalli, Akshay C Uttarkar, Suchithra Ventakesh, Sivarajan T Chettinar, Rishi Kumar Nageshan, Vidya Niranjan and Utpal S Tatu
Giardia lamblia (syn. Giardia duodenalis and Giardia intestinalis) is a major human infecting intestinal parasite. It is a frequent cause of endemic and epidemic diarrhea. G. lamblia is divided into eight genotypes (A-H) which infect a wide range of mammals and humans, but human infections are caused by Genotypes A and B only. Giardia lamblia strains are speculated to undergo zoonotic transmission and also considerable genetic variation has been identified. To unambiguously determine the genotype of the Indian isolate, we sequenced the genome to high depth coverage and compared the assemblies with the nearly completed WB and DH genome and draft genome of Genotypes E (P15; pig isolate) and B (GS and GS-B; human isolate).
Our results identified the Indian isolate to be very closely related to isolate WB and ~97.71% of the sequencing.. View More»
