Sunday Ahamefula Ezekwe
Nigeria
Research Article
GC-MS Analysis, Hypoglycemic Activity of Aqueous Root Extract of Carica papaya and Its Effects on Blood Lipid Profile and Hepatorenal Tissues Biomarkers of Diabetic Rats
Author(s): Sunday Ahamefula Ezekwe and Paul Chidoka ChikezieSunday Ahamefula Ezekwe and Paul Chidoka Chikezie
The likely phytocomponents, present in aqueous root extract (AqRE) of Carica papaya, responsible for hypoglycemic activity and their capacity to reverse altered blood lipid profile and compromised hepatorenal functions in alloxan-induced diabetic rats were investigated. The identification of main phytocomponents of AqRE of C. papaya was carried out using GC-MS system. The capacity of AqRE of C. papaya to reverse altered blood lipid profile and compromised hepatorenal functions were investigated using standard diagnostic techniques. The relative abundance of the 7 major phytocomponents present in AqRE of C. papaya was within the range of 3.49-35.63%. AqRE of C. papaya lowered elevated fasting blood glucose concentration of the diabetic rat group by 30.95%. The diabetic rat group treated with AqRE of C. papaya gave absolute values of TC-(HDL-C)]/(HDL-C=1.15 units, TC/ HDL-C=2.15 units a.. View More»
