Tetyana L Vasylyeva
Texas Tech Health Sciences Center,
Pediatrics, 1400 S. Coulter, Amarillo, TX 79106
Tanzania
Research Article
Correlation of Fibroblast Growth Factor 23 with Markers of Inflammation and Endothelial Dysfunction in End-Stage Renal Disease and Type 2 Diabetes Patients on Peritoneal Dialysis
Author(s): Ruchi Singh, Sudha P Chennasamudram, Sudip Sheth and Tetyana L VasylyevaRuchi Singh, Sudha P Chennasamudram, Sudip Sheth and Tetyana L Vasylyeva
Objective: This study was design to evaluate the correlation between FGF-23 and other cardiovascular risk factors (markers of endothelial dysfunction and inflammation) in ESRD patients with T2DM on PD.
Method: Sixty serum samples collected (four times, at weeks 0, 8, 10, and 18) from 15 patients with Type 2 Diabetes (T2DM) and ESRD on PD were analysed to study the relationship between the levels of FGF-23 and markers of endothelial dysfunction and inflammation. ELISA kits were used to quantitate Endothelin-1 (ET-1), soluble vascular adhesion molecule, Plasminogen Activator Inhibitor-1 (PAI-1), FGF-23, C-reactive protein, Interleukin-6 (IL-6), Tumor Necrosis Factor Alpha (TNF-α) and cluster of differentiation 146 (CD 146). The association between FGF-23, mineral metabolites, and markers of inflammation were analyzed using Spearman correlations. Linear regression models .. View More»