Xiaoli Wang
China
Research Article
Dysglycemia and Dyslipidemia Models in Nonhuman Primates: Part I. Model of Naturally Occurring Diabetes
Author(s): Xiaoli Wang, Bingdi Wang, Guofeng Sun, Jing Wu, Yongqiang Liu, Yixin (Jim) Wang and Yong-Fu XiaoXiaoli Wang, Bingdi Wang, Guofeng Sun, Jing Wu, Yongqiang Liu, Yixin (Jim) Wang and Yong-Fu Xiao
Insulin-resistant diabetes (Type 2 diabetes mellitus, T2DM) is one of the main comorbidities of obesity and is the most common form of diabetes. T2DM and obesity dynamically influence each other and often escalate patients’ other health issues. Cardiovascular, renal and other health consequences of obesity and diabetes have been studied for several decades. However, the underlying precise mechanisms and interactions of obesity and insulin-resistant diabetes have yet to be elucidated further. It has been recognized that sustained greater energy intake than expenditure is the main cause of obesity that can potentially lead to insulin resistance and diabetes due to excessive fat accumulation. To better understand the pathophysiology of human obesity and diabetes, nonhuman primate (NHP) models have been used for research to delineate molecular and cellular mechanisms because of the .. View More»
