Yadon Arad
Tiara Pharmaceuticals,
4546 B10 El Camino Real, #304, Los Altos CA 94022
Tanzania
Research Article
Adrenal Cortisol Hyper-Responsiveness as a Possible Cause of Obesity, Insulin Resistance and Cardiovascular Risk
Author(s): Yadon Arad, Simcha Pollack, Marguerite Roth and Alan D GuerciYadon Arad, Simcha Pollack, Marguerite Roth and Alan D Guerci
Introduction: Increased
cortisol
concentrations due to endogenous over-secretion or exogenous administration result in obesity, insulin resistance, and increased risk of cardiovascular disease (CVD). We wanted to assess whether non pathological adrenal hyper responsiveness to ACTH could reproduce these changes and thus explain how stress, via the pituitary-adrenal axis, can also cause such abnormalities. Methods: ACTH stimulation test was performed on 1072 non diabetic healthy participants in the St. Francis Heart Study and multiple blood tests, anthropometric measurements and coronary calcium scores were also obtained. Results: Post stimulation cortisol concentrations were correlated with obesity, insulin resistance, lipid abnormalities, Framingham scores (all p ≤ 0.01), but not with blood pressure and not with coronary calcium scores. In multivariate models, i.. View More»
