Department of Endocrinoslogy & Metabolism, University of Lagos, Nigeria
Editorial
Revealing VCAN as a Potential Common Diagnostic Biomarker of Renal Tubules and Glomerulus in Diabetic Kidney Disease
Author(s): Chinedu Okafor*
Diabetic kidney disease (DKD) is a leading cause of end-stage renal failure,
with pathogenesis affecting both the glomerular and tubular compartments
of the kidney. Identifying early, non-invasive, and common biomarkers
for these compartments is critical for timely diagnosis and intervention.
Versican (VCAN), a large extracellular matrix proteoglycan, has emerged as
a promising biomarker in renal pathophysiology. This article investigates
the expression and role of VCAN in both glomerular and tubular regions
in DKD, supported by transcriptomic analyses, immunohistochemistry, and
functional annotations. The findings highlight VCAN as a potential common
diagnostic indicator of DKD progression and severity, offering a unified
biomolecular perspective for clinical application.
Keywords: Diabetic kidney disease; VCAN; biomarker;.. View More»
